USC earned its first national title since 2013 by beating Stanford 14-12 in Palo Alto on Sunday. It marks the 10th national championship for the men's program.
The Trojans will face the winner of UCLA and George Washington.
UCLA and Cal defeated USC, forcing the team to earn an at-large bid to the NCAAs.
USC will host the MPSF Tournament this weekend for the conference title.
Two top-ranked teams battled in a close match at Uytengsu Aquatics Center.
The Trojans look to stay on top after a crosstown rivalry match on Saturday.
The Trojans bested two top-15 ranked opponents over the weekend.
The top-ranked Trojans will host Cal on Saturday before traveling to UC Irvine on Sunday.
The top-ranked USC Trojans (25-1) picked up their 25th win of the season on Saturday at Uytengsu Aquatics Center in a 10-5 victory over the No. 5 Pacific Tigers (7-11).
Both water polo teams will host alumni players on Saturday at home.