Tony Burnett took most of the first-team reps and eyes the starting safety spot.
Coming off a loss against Oregon State, USC will try to capture its eighth win of the season.
A year after being upset by Washington, the Trojans enter Saturday with a victory in mind.
Trojans have a seven-year winning streak against the Irish, and few have been close.
Seasoned veterans like Damian Williams and Ronald Johnson will be key to offset inexperience at quarterback.
Aaron Corp’s cracked fibula may pave the way for Matt Barkley to start as a true freshman.